Skin-Whitening and Antiwrinkle Proprieties of Maackia amurensis Methanolic Extract Lead Compounds

(1) Background: This study aimed to investigate the feasibility of using Maackia amurensis branch extract as a cosmetic ingredient with skin-whitening and antiwrinkle effects. (2) Methods: The effect M. was confirmed by investigating α-melanocyte-stimulating hormone (α-MSH)-induced melanin synthesis melanogenic protein expression in B16F1 cells. verified assessing matrix metalloproteinase (MMP)-1 soluble collagen content CCD-986sk major compounds were identified through isolation characterization high-performance liquid chromatography analysis. (3) Results: significantly inhibited α-MSH-induced 49%, 42%, 18% at 50, 37.5, 25 μg/mL concentrations, respectively, compared negative control (NC). also reduced microphthalmia-associated transcription factor, tyrosinase-related (TRP)-1, TRP-2, tyrosinase Furthermore, extracts decreased ultraviolet A-induced MMP-1 increased In addition, present found be formononetin, genistein, trans-resveratrol, piceatannol, tectoridin. (4) Conclusions: has properties. Therefore, it can used an functional cosmetics